The loading of the implant during activities of daily living is among the most important factors for the lifetime of the prosthesis. Since morphology and motions patterns are inter-individually different, the alignment of the prosthesis should be planned patient-specifically to avoid adverse loading conditions during activities of daily living. Within a clinical workflow the simulation time has to be minimized and the number of required input parameters should be reduced to avoid additional time-consuming and expensive data acquisition. Therefore, the development and validation of integrated morpho-functional models that can be efficiently personalized for each patient on the basis of standard clinical information is one major objective of our work.