In-vitro Parameter Studies for the Optimization of Knee Implants using an Experimental Knee Simulator

Experimental in-vitro testing on knee simulators play an important role in the understanding of the complex biomechanics of the human knee and offer great opportunities to perform parameter studies and evaluate new implant designs. Experimental ex-vivo parameters studies with our knee simulator are an essential complementary mean for comparison with in-silico model based biomechanical simulations and parameter optimization studies. For extensive parameter optimization, both methods should enable fast and easy biomechanical analysis with various implant geometries. However, whereas in-silico parameter variation is easy and cheap, manufacturing of CoCr implants for experimental ex-vivo studies is very costly and time consuming. Therefore, different rapid prototyping (3D-printing) technologies and processes are used to evaluate implant geometries during passive, semi-active and active knee motion.

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  • M. Asseln, S.A.G.A. Grothues & K. Radermacher: Relationship between the form and function of implant design in total knee replacement. Journal of Biomechanics, 2021, 119, pp. 110296 [DOI: 10.1016/j.jbiomech.2021.110296]
  • M. Asseln: Morphological and Functional Analysis of the Knee Joint for Implant Design Optimization. In: S. Leonhardt, K. Radermacher & T. Schmitz-Rode (ed.): 57, Aachener Beiträge zur Medizintechnik (ISBN 978-3-8440-7047-7), Shaker, 2019, pp. 306
  • M. Asseln, L. Berger, M. Verjans & K. Radermacher: Effects of the medial and lateral tibial slope on knee joint kinematics in total knee arthroplasty. Current Directions in Biomedical Engineering, 2018, 4(1), pp. 207-211 [DOI: 10.1515/cdbme-2018-0051]
  • M. Asseln, M. Verjans, D. Zanke & K. Radermacher: Morpho-Functional Analysis of Knee Implant Design for Total Knee Arthroplasty on the Example of the Trochlear Groove Orientation. In: K. Radermacher & F. Rodriguez Y Baena (ed.): CAOS2017. EPiC Series in Health Sciences, 1, 2017, pp. 233-237
  • M. Verjans, K. Radermacher & M. Asseln: Rapid Prototyping von Knieendoprothesen für In-vitro-Versuche. 10. Jahrestagung der Deutschen Gesellschaft für Biomechanik (DGfB), 2017, pp. 14-15
  • M. Verjans, M. Asseln & K. Radermacher: Rapid Prototyping of replica knee implants for in vitro testing. Current Directions in Biomedical Engineering, 2016, 2(1), pp. 553-556 [DOI: 10.1515/cdbme-2016-0122]