Investigation of the dynamic craniospinal compliance for the therapy of normal pressure hydrocephalus (DynaCephalus)
Overview
The number of patients suffering from Normal Pressure Hydrocephalus (NPH), a pathological enlargement of the inner cerebrospinal fluid (CSF) spaces without accompanying pressure rise, has increased in recent years. Currently the pathophysiology is not completely understood, but it is known that reduced intracranial compliance plays an important role in the pathogenesis. Therefore, this research project aims to investigate the intracranial compliance especially concerning its dynamics, which has only been insufficiently analyzed in its relation to NPH, and to develop new therapeutic and diagnostic options for this disease.
In order to understand the underlying mechanism leading to a reduced intracranial compliance better, this project initially focuses on the modeling of parameters so far not investigated to perform a sensitivity analysis.
Approach
- Theoretical investigation
- Experimental investigation
Funding
The project DynaCephalus is funded by the German Research Foundation.
(Project term: 2015 - 2019)
Partner
- Philips Chair for Medical Information Technology (MedIT), Helmholtz-Institute for Biomedical Engineering at RWTH Aachen University
Associated partner
(cooperation funded by DAAD):
- Dr. Olivier Balédent, Bio Flow Image Processing Group (University Hospital of Picardy Jules Verne, Amiens, Frankreich)
Publications
- C. Goffin: Modellbasierte Biomechanische Untersuchungen der Statischen und Dynamischen Compliance bei Normaldruckhydrocephalus. In: S. Leonhardt, K. Radermacher & T. Schmitz-Rode (ed.): 58, Aachener Beiträge zur Medizintechnik (ISBN 978-3-8440-7368-3), Shaker, 2020, pp. 218
- A. Benninghaus, O. Balédent, A. Lokossou, C. Castelar, S. Leonhardt & K. Radermacher: Enhanced in vitro model of the CSF dynamics. Fluids and barriers of the CNS, 2019, 16(1), pp. 1-11 [DOI: 10.1186/s12987-019-0131-z]
- A. Benninghaus, C. Goffin, S. Leonhardt & K. Radermacher: Functional modeling of the craniospinal system for in-vitro parameter studies on the pathogenesis of NPH. Current Directions in Biomedical Engineering, 2017, 3(2), pp. 825-828 [DOI: 10.1515/cdbme-2017-0173]
- C. Goffin, S. Leonhardt & K. Radermacher: The Role of a Dynamic Craniospinal Compliance in NPH - A Review and Future Challenges. IEEE Reviews in Biomedical Engineering, 2017, pp. 310-322 [DOI: 10.1109/RBME.2016.2620493]
- C. Goffin, A. Holterhoff, S. Leonhardt & K. Radermacher: Modelling and Understanding Normal Pressure Hydrocephalus. In: D.A. Jaffray (ed.): IUPESM World Congress on Medical Physics and Biomedical Engineering(ISBN 978-3-319-19387-8), 2015, pp. 333-337 [DOI: 10.1007/978-3-319-19387-8_80]