The number of patients suffering from Normal Pressure Hydrocephalus (NPH), a pathological enlargement of the inner cerebrospinal fluid (CSF) spaces without accompanying pressure rise, has increased in recent years. Currently the pathophysiology is not completely understood, but it is known that reduced intracranial compliance plays an important role in the pathogenesis. Therefore, this research project aims to investigate the intracranial compliance especially concerning its dynamics, which has only been insufficiently analyzed in its relation to NPH, and to develop new therapeutic and diagnostic options for this disease.
In order to understand the underlying mechanism leading to a reduced intracranial compliance better, this project initially focuses on the modeling of parameters so far not investigated to perform a sensitivity analysis.
The project DynaCephalus is funded by the German Research Foundation.
(Project term: 2015 - 2019)
(cooperation funded by DAAD):