Evaluation of extracorporeal shock wave therapy
Shock waves have been used since the 1980s for non-invasive destruction of kidney stones. Here, sound pulses with pressures of up to 150MPa and rise times in the nanosecond range are generated by a sound source and focused on the stone by means of suitable reflectors or surface geometry in the patient's body.
During the treatment of kidney stones it was found that shock waves have a positive influence on bone growth. Since then shock waves have been successfully used for a variety of therapeutic applications, such as pseudarthrosis and tendinopathies. In addition, shock waves are also used in many other areas, mostly empirically.
For all these applications it is not yet clear which shock wave or sound field parameters are necessary for a successful therapy. In order to investigate this relationship in more detail, simulations, experimental setups and clinical studies are carried out together with biological and clinical partners from different disciplines.
Publications
- N. Reinhardt, C. Schmitz, S. Milz & M. de la Fuente: Influence of the skull bone and brain tissue on the sound field in transcranial extracorporeal shock wave therapy: an ex vivo study. Biomedical Engineering / Biomedizinische Technik, 2024, 69(1), pp. 27-37 [DOI: 10.1515/bmt-2022-0332]
- E.-M. Haddouti, N. Reinhardt, R. Ossendorff, C. Burger, D.C. Wirtz, M. de la Fuente & F.A. Schildberg: Effects of single and repeated shock wave application on the osteogenic differentiation potential of human primary mesenchymal stromal cells and the osteoblastic cell line MG63 in vitro. Frontiers in Bioengineering and Biotechnology, 2023, 11, pp. 1-17 [DOI: 10.3389/fbioe.2023.1207655]
- M. Gatz, S. Schweda, M. Betsch, T. Dirrichs, M. de la Fuente, N. Reinhardt & V. Quack: Line- and Point-Focused Extracorporeal Shock Wave Therapy for Achilles Tendinopathy: A Placebo-Controlled RCT Study. Sports Health: A Multidisciplinary Approach, 2021, 13(5), pp. 511-518 [DOI: 10.1177/1941738121991791]
- K. Sternecker, J. Geist, S. Beggel, K. Dietz-Laursonn, M. de la Fuente, H.-G. Frank, J.P. Furia, S. Milz & C. Schmitz: Exposure of zebra mussels to extracorporeal shock waves demonstrates formation of new mineralized tissue inside and outside the focus zone. Biology open, 2018, 7(7), pp. 1-12 [DOI: 10.1242/bio.033258]
- N. Reinhardt, K. Dietz-Laursonn, M. Janzen, C. Bach, K. Radermacher & M. de la Fuente: Experimental setup for evaluation of cavitation effects in ESWL. Current Directions in Biomedical Engineering, 2018, 4(1), pp. 191-194 [DOI: 10.1515/cdbme-2018-0047]
- K. Dietz-Laursonn, R. Beckmann, S. Ginter, K. Radermacher & M. de la Fuente: In-vitro cell treatment with focused shockwaves—influence of the experimental setup on the sound field and biological reaction. Journal of Therapeutic Ultrasound, 2016, 4(10), pp. 1-14 [DOI: 10.1186/s40349-016-0053-z]
- M. de la Fuente, K. Dietz-Laursonn, F. Ueberle & V. Auersperg: Recommendation statement of the Conjoint Physics Working Group of ISMST and DIGEST on ESWT study design and publication. 4th ISMST Basic Research Meeting Vienna, 2016, pp. 14
- M. Becker, A. Goetzenich, A.B. Roehl, C. Huebel, M. de la Fuente, K. Dietz-Laursonn, K. Radermacher, R. Rossaint & M. Hein: Myocardial effects of local shock wave therapy in a Langendorff model. Ultrasonics, 2014, 54(1), pp. 131-136 [DOI: 10.1016/j.ultras.2013.07.005]
- K. Dietz-Laursonn, K. Radermacher & M. de la Fuente: Influence of Different In-Vitro Setups on Shockwave Treatment Parameters – a Guide for More Comparable Results. 17th congress of the International Society for Medical Shockwave Treatment, 2014
- K. Dietz-Laursonn, S. Mertens, R. Beckmann, A. Götzenich, T.T. Sönmez, K. Radermacher & M. de la Fuente: Why the mechanisms of shockwave therapy are still not understood. 16th congress of the International Society for Medical Shockwave Treatment, 2013
- A. Goetzenich, C. Hübel, M. de la Fuente, M. Becker, K. Radermacher, M. Hein, R. Autschbach & A. Röhl: Myocardial effects of local shock wave therapy in a Langendorff model. Thorac cardiovasc Surg, 61(S 01), 2013, pp. P32 [DOI: 10.1055/s-0032-1332672]
- K. Dietz-Laursonn, R. Beckmann, T. Pufe, K. Radermacher & M. de la Fuente: Evaluation of the comparability of in-vitro and in-vivo shockwave treatment. 15th congress of the International Society for Medical Shockwave Treatment, 2012
- K. Dietz-Laursonn, A. Houben, R. Beckmann, T. Pufe, K. Radermacher & M. de la Fuente: Investigation of the correlation between shockwave induced mechanical stress and biological response. 2nd basic research meeting of the International Society for Medical Shockwave Treatment, 2012
- M. de la Fuente, Y. Long, M. Hein, A. Röhl, M. Becker & K. Radermacher: Investigation of the correlation between shockwave induced mechanical stress and biological response. 14th congress of the International Society for Medical Shockwave Treatment, 2011, pp. 12