NPH is a disease that occurs mainly after the age of 65 and involves three common symptoms - gait disturbance, dementia and incontinence. It is believed that approximately 10% of all dementia patients are actually NPH patients. Magnetic resonance imaging can show loss of brain tissue and increased accumulation of cerebrospinal fluid ("CSF" - also called "cerebrospinal fluid") surrounding the brain, spinal cord and nerve roots down to the lumbar spine. The flow dynamics of the CSF, particularly in the spinal region, is also altered. However, the causes of NPH are still completely unclear. In addition, so-called "redundant nerve roots" (RNR), tangled, hypertrophied and congested nerve fibers, are observed in the area of stenoses of the spinal canal. These not only exacerbate the problem of stenosis, but are also thought to be caused by the morphological changes in the spine. The phenomenon of RNR is accompanied by corresponding neurological complaints, and a connection with the problem of NPH is likely. However, also in this case the actual causes are unknown so far and will be investigated by experimental as well as theoretical studies in collaboration with clinical partners. By modeling (in vitro and in silico) the CSF dynamics, effects and influencing factors of pathologic changes can be investigated, among others, in sensitivity analyses of the dynamic fluid system as a basis for the development of new diagnostic and therapeutic options.

Cooperation partner

  • Dr. Olivier Balédent, Bio Flow Image Processing Group, University Hospital of Picardy Jules Verne, Amiens, France, (cooperation funded by DAAD)
  • Univ.-Prof. Dr. med. Hans Clusmann and Dr. med. Chuh-Hyoun Na, Neurosurgery Clinic, Uniklinik RWTH Aachen
  • Prof. Dr. med. Uwe Kehler, Asklepios Klinik, Hamburg Altona
  • Prof. Dr. med. Luca Papavero, Neurosurgery, Universität Hamburg

Current Projects

Former Projects

  • DynaCephalus - Investigation of the dynamic craniospinal compliance for the therapy of NPH (2015 - 2019)


  • A. Benninghaus, F. Huber, A. Müller & K. Radermacher: Experimental investigation of the influence of pathological blood dynamics on the CSF system with regard to normal pressure hydrocephalus. Abstracts from Hydrocephalus 2022: the Fourteenth Meeting of the Hydrocephalus Society, Fluids and Barriers of the CNS, 19(104), 2023 [DOI: 10.1186/s12987-022-00397-x]
  • A. Benninghaus, L. Stellmann, U. Kehler & K. Radermacher: In vitro investigation of the influence of cervical spinal canal stenosis on CSF hydrodynamics. Abstracts from Hydrocephalus 2021: The Thirteenth Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders, Fluids and barriers of the CNS, 18(60), 2021 [DOI: 10.1186/s12987-021-00293-w]
  • C. Goffin: Modellbasierte Biomechanische Untersuchungen der Statischen und Dynamischen Compliance bei Normaldruckhydrocephalus. In: S. Leonhardt, K. Radermacher & T. Schmitz-Rode (ed.): 58, Aachener Beiträge zur Medizintechnik (ISBN 978-3-8440-7368-3), Shaker, 2020, pp. 218
  • A. Benninghaus, O. Balédent, A. Lokossou, C. Castelar, S. Leonhardt & K. Radermacher: Enhanced in vitro model of the CSF dynamics. Fluids and barriers of the CNS, 2019, 16(1), pp. 1-11 [DOI: 10.1186/s12987-019-0131-z]
  • A. Benninghaus, C. Goffin, S. Leonhardt & K. Radermacher: Functional modeling of the craniospinal system for in-vitro parameter studies on the pathogenesis of NPH. Current Directions in Biomedical Engineering, 2017, 3(2), pp. 825-828 [DOI: 10.1515/cdbme-2017-0173]
  • C. Goffin, S. Leonhardt & K. Radermacher: The Role of a Dynamic Craniospinal Compliance in NPH - A Review and Future Challenges. IEEE Reviews in Biomedical Engineering, 2017, pp. 310-322 [DOI: 10.1109/RBME.2016.2620493]
  • C. Goffin, A. Holterhoff, S. Leonhardt & K. Radermacher: Modelling and Understanding Normal Pressure Hydrocephalus. In: D.A. Jaffray (ed.): IUPESM World Congress on Medical Physics and Biomedical Engineering(ISBN 978-3-319-19387-8 ), 2015, pp. 333-337 [DOI: 10.1007/978-3-319-19387-8_80]